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CpG interval report generated on 20/05/20 with pycoMeth 0.4.6
Interval details
| pvalue rank | chromosome | start | end | length | number of samples | number of CpGs | pvalue | adjusted pvalue |
|---|---|---|---|---|---|---|---|---|
| #130 | 17 | 74356576 | 74357824 | 1248 | 3 | 39 | 2.1207e-16 | 1.62234e-14 |
Methylation log-likelihood ratio by CpG position
Distribution of CpG methylation log-likelihood ratio by sample
Closest transcripts TSS
| distance to tss | transcript id | gene id | transcript name | chromosome | start | end | strand | feature type | transcript biotype |
|---|---|---|---|---|---|---|---|---|---|
| 4044 | enst00000375366 | sg00000204347 | btbd17-201 | 17 | 74356416 | 74361868 | - | mRNA | protein_coding |
| -7986 | enst00000549637 | sg00000196169 | kif19-204 | 17 | 74348590 | 74350481 | + | lnc_RNA | retained_intron |
| 9583 | enst00000582579 | sg00000257008 | gpr142-202 | 17 | 74367407 | 74372622 | + | mRNA | nonsense_mediated_decay |
| 9634 | enst00000585308 | sg00000257008 | gpr142-203 | 17 | 74367458 | 74371840 | + | mRNA | nonsense_mediated_decay |
| 9634 | enst00000335666 | sg00000257008 | gpr142-201 | 17 | 74367458 | 74372600 | + | mRNA | protein_coding |
| -30319 | enst00000547389 | sg00000196169 | kif19-203 | 17 | 74326257 | 74351319 | + | lnc_RNA | retained_intron |
| -30345 | enst00000359939 | sg00000196169 | kif19-201 | 17 | 74326231 | 74351345 | + | lnc_RNA | retained_intron |
| -30350 | enst00000551017 | sg00000196169 | kif19-205 | 17 | 74326226 | 74329466 | + | lnc_RNA | retained_intron |
| -30350 | enst00000389916 | sg00000196169 | kif19-202 | 17 | 74326226 | 74355820 | + | mRNA | protein_coding |
| -30366 | enst00000551294 | sg00000196169 | kif19-206 | 17 | 74326210 | 74352326 | + | mRNA | protein_coding |
| -42732 | enst00000579312 | sg00000171595 | dnai2-204 | 17 | 74313844 | 74314880 | + | lnc_RNA | retained_intron |
| -46786 | enst00000585167 | sg00000266106 | ac103809.1-201 | 17 | 74307210 | 74309790 | - | lnc_RNA | lncrna |
| 59880 | enst00000363151 | sg00000200021 | rna5sp448-201 | 17 | 74417594 | 74417704 | - | pseudogenic_transcript | rrna_pseudogene |
| 67027 | enst00000582444 | sg00000170412 | gprc5c-209 | 17 | 74424851 | 74440212 | + | mRNA | protein_coding |
| 73560 | enst00000342648 | sg00000170412 | gprc5c-201 | 17 | 74431384 | 74447429 | + | mRNA | protein_coding |
| 73704 | enst00000652232 | sg00000170412 | gprc5c-212 | 17 | 74431528 | 74447427 | + | mRNA | protein_coding |
| 73704 | enst00000481232 | sg00000170412 | gprc5c-205 | 17 | 74431528 | 74447429 | + | mRNA | protein_coding |
| 74264 | enst00000392627 | sg00000170412 | gprc5c-202 | 17 | 74432088 | 74447429 | + | mRNA | protein_coding |
| 74292 | enst00000392628 | sg00000170412 | gprc5c-203 | 17 | 74432116 | 74449509 | + | mRNA | protein_coding |
| 74309 | enst00000582473 | sg00000170412 | gprc5c-210 | 17 | 74432133 | 74439937 | + | mRNA | protein_coding |
| -75064 | enst00000446837 | sg00000171595 | dnai2-202 | 17 | 74281512 | 74314883 | + | mRNA | protein_coding |
| -75064 | enst00000579490 | sg00000171595 | dnai2-205 | 17 | 74281512 | 74314884 | + | mRNA | protein_coding |
| 75873 | enst00000392629 | sg00000170412 | gprc5c-204 | 17 | 74433697 | 74447028 | + | mRNA | protein_coding |
| 75873 | enst00000652294 | sg00000170412 | gprc5c-213 | 17 | 74433697 | 74447427 | + | mRNA | protein_coding |
| 82072 | enst00000581590 | sg00000170412 | gprc5c-208 | 17 | 74439896 | 74451653 | + | mRNA | protein_coding |
| -82320 | enst00000579055 | sg00000171595 | dnai2-203 | 17 | 74274256 | 74314884 | + | mRNA | nonsense_mediated_decay |
| -82329 | enst00000582036 | sg00000171595 | dnai2-206 | 17 | 74274247 | 74314884 | + | mRNA | protein_coding |
| -82342 | enst00000311014 | sg00000171595 | dnai2-201 | 17 | 74274234 | 74314884 | + | mRNA | protein_coding |
| 85253 | enst00000582873 | sg00000170412 | gprc5c-211 | 17 | 74443077 | 74447088 | + | lnc_RNA | processed_transcript |
| 85261 | enst00000482723 | sg00000170412 | gprc5c-206 | 17 | 74443085 | 74450580 | + | lnc_RNA | retained_intron |
| 87380 | enst00000577663 | sg00000170412 | gprc5c-207 | 17 | 74445204 | 74447427 | + | lnc_RNA | retained_intron |
| -94556 | enst00000583018 | sg00000264272 | ac100786.2-201 | 17 | 74256896 | 74262020 | - | lnc_RNA | lncrna |
| -106619 | enst00000526858 | sg00000141540 | ttyh2-203 | 17 | 74249957 | 74260206 | + | mRNA | nonsense_mediated_decay |
| -107211 | enst00000534039 | sg00000141540 | ttyh2-207 | 17 | 74249365 | 74250730 | + | lnc_RNA | retained_intron |
| -107252 | enst00000528152 | sg00000141540 | ttyh2-205 | 17 | 74249324 | 74253246 | + | lnc_RNA | retained_intron |
| 108575 | enst00000648095 | sg00000167851 | cd300a-207 | 17 | 74466399 | 74484794 | + | mRNA | protein_coding |
| -108618 | enst00000441391 | sg00000141540 | ttyh2-202 | 17 | 74247958 | 74262016 | + | mRNA | protein_coding |
| 108810 | enst00000360141 | sg00000167851 | cd300a-202 | 17 | 74466634 | 74484794 | + | mRNA | protein_coding |
| 108834 | enst00000392625 | sg00000167851 | cd300a-204 | 17 | 74466658 | 74484790 | + | mRNA | protein_coding |
| 108851 | enst00000310828 | sg00000167851 | cd300a-201 | 17 | 74466675 | 74484167 | + | mRNA | protein_coding |
| 108851 | enst00000361933 | sg00000167851 | cd300a-203 | 17 | 74466675 | 74484167 | + | mRNA | protein_coding |
| 108852 | enst00000582319 | sg00000167851 | cd300a-206 | 17 | 74466676 | 74484168 | + | lnc_RNA | retained_intron |
| 109038 | enst00000577511 | sg00000167851 | cd300a-205 | 17 | 74466862 | 74484296 | + | mRNA | protein_coding |
| -113202 | enst00000528128 | sg00000141540 | ttyh2-204 | 17 | 74243374 | 74252288 | + | mRNA | nonsense_mediated_decay |
| -115776 | enst00000534346 | sg00000141540 | ttyh2-208 | 17 | 74240800 | 74250014 | + | lnc_RNA | processed_transcript |
| -133932 | enst00000578825 | sg00000141540 | ttyh2-209 | 17 | 74222644 | 74244073 | + | lnc_RNA | retained_intron |
| -140960 | enst00000529107 | sg00000141540 | ttyh2-206 | 17 | 74215616 | 74260651 | + | mRNA | protein_coding |
| -143005 | enst00000269346 | sg00000141540 | ttyh2-201 | 17 | 74213571 | 74262020 | + | mRNA | protein_coding |
| -143234 | enst00000532794 | sg00000246731 | ac100786.1-202 | 17 | 74211486 | 74213342 | - | lnc_RNA | lncrna |
| -143234 | enst00000670574 | sg00000246731 | ac100786.1-205 | 17 | 74210012 | 74213342 | - | lnc_RNA | lncrna |
| -143234 | enst00000662857 | sg00000246731 | ac100786.1-204 | 17 | 74210012 | 74213342 | - | lnc_RNA | lncrna |
| -143255 | enst00000499670 | sg00000246731 | ac100786.1-201 | 17 | 74209980 | 74213321 | - | lnc_RNA | lncrna |
| -143268 | enst00000531617 | sg00000246731 | ac100786.1-203 | 17 | 74212674 | 74213308 | - | lnc_RNA | lncrna |
| -152872 | enst00000528433 | sg00000172809 | rpl38-203 | 17 | 74203704 | 74204190 | + | mRNA | protein_coding |
| -152872 | enst00000533498 | sg00000172809 | rpl38-206 | 17 | 74203704 | 74209896 | + | mRNA | protein_coding |
| -152882 | enst00000534490 | sg00000172809 | rpl38-207 | 17 | 74203694 | 74209461 | + | mRNA | protein_coding |
| -152883 | enst00000584577 | sg00000172809 | rpl38-208 | 17 | 74203693 | 74209878 | + | mRNA | protein_coding |
| -152898 | enst00000311111 | sg00000172809 | rpl38-201 | 17 | 74203678 | 74210655 | + | mRNA | protein_coding |
| -152901 | enst00000529123 | sg00000172809 | rpl38-204 | 17 | 74203675 | 74204593 | + | lnc_RNA | retained_intron |
| -152914 | enst00000530646 | sg00000172809 | rpl38-205 | 17 | 74203662 | 74206283 | + | lnc_RNA | retained_intron |
| -152994 | enst00000439590 | sg00000172809 | rpl38-202 | 17 | 74203582 | 74209880 | + | mRNA | protein_coding |
| 173650 | enst00000314401 | sg00000178789 | cd300lb-201 | 17 | 74523153 | 74531474 | - | mRNA | protein_coding |
| 173651 | enst00000392621 | sg00000178789 | cd300lb-202 | 17 | 74521174 | 74531475 | - | mRNA | protein_coding |
| 188291 | enst00000330793 | sg00000167850 | cd300c-201 | 17 | 74541073 | 74546115 | - | mRNA | protein_coding |
| 194913 | enst00000430386 | sg00000236770 | ac079325.1-201 | 17 | 74549399 | 74552737 | - | pseudogenic_transcript | unprocessed_pseudogene |
| -202364 | enst00000584003 | sg00000266357 | linc02074-202 | 17 | 74064357 | 74154212 | - | lnc_RNA | lncrna |
| 209519 | enst00000641710 | sg00000284690 | cd300h-202 | 17 | 74560701 | 74567343 | - | mRNA | polymorphic_pseudogene |
| 209519 | enst00000651677 | sg00000284690 | cd300h-203 | 17 | 74560701 | 74567343 | - | mRNA | protein_coding |
| 209519 | enst00000641031 | sg00000284690 | cd300h-201 | 17 | 74560781 | 74567343 | - | mRNA | polymorphic_pseudogene |
| 209519 | enst00000651881 | sg00000284690 | cd300h-204 | 17 | 74560781 | 74567343 | - | mRNA | protein_coding |
| 226855 | enst00000524389 | sg00000182352 | c17orf77-203 | 17 | 74584679 | 74592161 | + | lnc_RNA | lncrna |
| 227094 | enst00000392620 | sg00000182352 | c17orf77-202 | 17 | 74584918 | 74594209 | + | lnc_RNA | lncrna |
| 232678 | enst00000328023 | sg00000182352 | c17orf77-201 | 17 | 74590502 | 74594209 | + | lnc_RNA | lncrna |
| 234459 | enst00000375352 | sg00000204345 | cd300ld-201 | 17 | 74579365 | 74592283 | - | mRNA | protein_coding |
| 242016 | enst00000581412 | sg00000261222 | ac064805.1-201 | 17 | 74599840 | 74604269 | + | lnc_RNA | lncrna |
| -243674 | enst00000653467 | sg00000266357 | linc02074-203 | 17 | 74062113 | 74112902 | - | lnc_RNA | lncrna |
| -243674 | enst00000668167 | sg00000266357 | linc02074-206 | 17 | 74062111 | 74112902 | - | lnc_RNA | lncrna |
| -243674 | enst00000654301 | sg00000266357 | linc02074-204 | 17 | 74062111 | 74112902 | - | lnc_RNA | lncrna |
| -243674 | enst00000666198 | sg00000266357 | linc02074-205 | 17 | 74063894 | 74112902 | - | lnc_RNA | lncrna |
| -243677 | enst00000581028 | sg00000266357 | linc02074-201 | 17 | 74043452 | 74112899 | - | lnc_RNA | lncrna |
| 245913 | enst00000569279 | sg00000261222 | ac064805.1-202 | 17 | 74603737 | 74607229 | + | lnc_RNA | lncrna |
| 247157 | enst00000577560 | sg00000261222 | ac064805.1-203 | 17 | 74604981 | 74607229 | + | lnc_RNA | lncrna |
| 261523 | enst00000412268 | sg00000186407 | cd300e-202 | 17 | 74617147 | 74619347 | - | mRNA | protein_coding |
| 265914 | enst00000392619 | sg00000186407 | cd300e-201 | 17 | 74609885 | 74623738 | - | mRNA | protein_coding |
| 312754 | enst00000340415 | sg00000172794 | rab37-201 | 17 | 74670578 | 74747334 | + | mRNA | protein_coding |
| 313317 | enst00000402449 | sg00000172794 | rab37-208 | 17 | 74671141 | 74745874 | + | mRNA | protein_coding |
| 313356 | enst00000392617 | sg00000172794 | rab37-207 | 17 | 74671180 | 74747335 | + | lnc_RNA | retained_intron |
| 319776 | enst00000582959 | sg00000264659 | ac064805.2-203 | 17 | 74672712 | 74677600 | - | lnc_RNA | lncrna |
| 319796 | enst00000665064 | sg00000264659 | ac064805.2-201 | 17 | 74670077 | 74677620 | - | lnc_RNA | lncrna |
| 319800 | enst00000663016 | sg00000264659 | ac064805.2-202 | 17 | 74670077 | 74677624 | - | lnc_RNA | lncrna |
| 347431 | enst00000581500 | sg00000186074 | cd300lf-208 | 17 | 74695753 | 74705255 | - | mRNA | protein_coding |
| 347431 | enst00000361254 | sg00000186074 | cd300lf-204 | 17 | 74694311 | 74705255 | - | mRNA | protein_coding |
| 347431 | enst00000343125 | sg00000186074 | cd300lf-203 | 17 | 74694311 | 74705255 | - | mRNA | protein_coding |
| 347486 | enst00000464910 | sg00000186074 | cd300lf-206 | 17 | 74695037 | 74705310 | - | mRNA | protein_coding |
| 347486 | enst00000462044 | sg00000186074 | cd300lf-205 | 17 | 74695037 | 74705310 | - | mRNA | nonsense_mediated_decay |
| 355099 | enst00000326165 | sg00000186074 | cd300lf-202 | 17 | 74694317 | 74712923 | - | mRNA | protein_coding |
| 355101 | enst00000583544 | sg00000186074 | cd300lf-209 | 17 | 74704352 | 74712925 | - | lnc_RNA | retained_intron |
| 355117 | enst00000583937 | sg00000186074 | cd300lf-210 | 17 | 74694814 | 74712941 | - | mRNA | protein_coding |
| 355130 | enst00000301573 | sg00000186074 | cd300lf-201 | 17 | 74694318 | 74712954 | - | mRNA | protein_coding |
| 355154 | enst00000469092 | sg00000186074 | cd300lf-207 | 17 | 74694317 | 74712978 | - | mRNA | protein_coding |
| 378774 | enst00000528438 | sg00000172794 | rab37-212 | 17 | 74736598 | 74746192 | + | mRNA | protein_coding |
| 378996 | enst00000392615 | sg00000172794 | rab37-206 | 17 | 74736820 | 74747300 | + | mRNA | protein_coding |
| 379093 | enst00000392614 | sg00000172794 | rab37-205 | 17 | 74736917 | 74747335 | + | mRNA | protein_coding |
| 379395 | enst00000533530 | sg00000172794 | rab37-214 | 17 | 74737219 | 74744465 | + | lnc_RNA | retained_intron |
| 379397 | enst00000527040 | sg00000172794 | rab37-211 | 17 | 74737221 | 74744559 | + | lnc_RNA | retained_intron |
| 379397 | enst00000577548 | sg00000172794 | rab37-215 | 17 | 74737221 | 74745028 | + | lnc_RNA | retained_intron |
| 379406 | enst00000392612 | sg00000172794 | rab37-203 | 17 | 74737230 | 74747335 | + | mRNA | protein_coding |
| 379408 | enst00000392610 | sg00000172794 | rab37-202 | 17 | 74737232 | 74747335 | + | mRNA | protein_coding |
| 379432 | enst00000392613 | sg00000172794 | rab37-204 | 17 | 74737256 | 74747335 | + | mRNA | protein_coding |
| 379447 | enst00000613645 | sg00000172794 | rab37-216 | 17 | 74737271 | 74747334 | + | mRNA | protein_coding |
| 379447 | enst00000481224 | sg00000172794 | rab37-209 | 17 | 74737271 | 74747335 | + | mRNA | nonsense_mediated_decay |
| 387017 | enst00000488977 | sg00000172794 | rab37-210 | 17 | 74744841 | 74747334 | + | lnc_RNA | retained_intron |
| 387034 | enst00000531420 | sg00000172794 | rab37-213 | 17 | 74744858 | 74745794 | + | lnc_RNA | retained_intron |
| 390789 | enst00000581999 | sg00000284186 | mir3615-201 | 17 | 74748613 | 74748699 | + | miRNA | mirna |
| 390804 | enst00000262613 | sg00000109062 | slc9a3r1-201 | 17 | 74748628 | 74769353 | + | mRNA | protein_coding |
| 390828 | enst00000583369 | sg00000109062 | slc9a3r1-205 | 17 | 74748652 | 74768582 | + | mRNA | protein_coding |
| 391088 | enst00000585285 | sg00000266036 | ac016888.1-201 | 17 | 74747319 | 74748912 | - | lnc_RNA | lncrna |
| 404179 | enst00000413388 | sg00000109062 | slc9a3r1-202 | 17 | 74762003 | 74769296 | + | mRNA | protein_coding |
| 405206 | enst00000578958 | sg00000109062 | slc9a3r1-203 | 17 | 74763030 | 74768559 | + | lnc_RNA | retained_intron |
| 405604 | enst00000581356 | sg00000109062 | slc9a3r1-204 | 17 | 74763428 | 74768803 | + | mRNA | nonsense_mediated_decay |
| -406670 | enst00000647802 | sg00000285648 | ac137735.2-201 | 17 | 73926421 | 73949906 | - | lnc_RNA | lncrna |
| 414645 | enst00000581762 | sg00000109065 | nat9-215 | 17 | 74771625 | 74772469 | - | lnc_RNA | retained_intron |
| 416275 | enst00000581466 | sg00000109065 | nat9-214 | 17 | 74772272 | 74774099 | - | mRNA | protein_coding |
| 417883 | enst00000580632 | sg00000109065 | nat9-211 | 17 | 74771558 | 74775707 | - | mRNA | protein_coding |
| 418269 | enst00000578947 | sg00000109065 | nat9-206 | 17 | 74772903 | 74776093 | - | mRNA | protein_coding |
| 418304 | enst00000581451 | sg00000109065 | nat9-213 | 17 | 74773609 | 74776128 | - | mRNA | protein_coding |
| 418474 | enst00000578822 | sg00000109065 | nat9-204 | 17 | 74771695 | 74776298 | - | mRNA | protein_coding |
| 418480 | enst00000580216 | sg00000109065 | nat9-209 | 17 | 74772238 | 74776304 | - | lnc_RNA | processed_transcript |
| 418499 | enst00000582870 | sg00000109065 | nat9-220 | 17 | 74771660 | 74776323 | - | mRNA | protein_coding |
| 418499 | enst00000582359 | sg00000109065 | nat9-218 | 17 | 74772673 | 74776323 | - | lnc_RNA | retained_intron |
| 418499 | enst00000583834 | sg00000109065 | nat9-225 | 17 | 74770581 | 74776323 | - | lnc_RNA | retained_intron |
| 418500 | enst00000581136 | sg00000109065 | nat9-212 | 17 | 74771389 | 74776324 | - | mRNA | protein_coding |
| 418507 | enst00000584022 | sg00000109065 | nat9-227 | 17 | 74771691 | 74776331 | - | mRNA | nonsense_mediated_decay |
| 418507 | enst00000579218 | sg00000109065 | nat9-207 | 17 | 74771794 | 74776331 | - | mRNA | protein_coding |
| 418512 | enst00000579837 | sg00000109065 | nat9-208 | 17 | 74775360 | 74776336 | - | lnc_RNA | retained_intron |
| 418513 | enst00000578862 | sg00000109065 | nat9-205 | 17 | 74772175 | 74776337 | - | lnc_RNA | retained_intron |
| 418513 | enst00000583476 | sg00000109065 | nat9-222 | 17 | 74771768 | 74776337 | - | mRNA | protein_coding |
| 418515 | enst00000580301 | sg00000109065 | nat9-210 | 17 | 74770567 | 74776339 | - | mRNA | protein_coding |
| 418518 | enst00000583757 | sg00000109065 | nat9-224 | 17 | 74771728 | 74776342 | - | mRNA | protein_coding |
| 418521 | enst00000357814 | sg00000109065 | nat9-201 | 17 | 74770529 | 74776345 | - | mRNA | protein_coding |
| 418521 | enst00000583989 | sg00000109065 | nat9-226 | 17 | 74772266 | 74776345 | - | lnc_RNA | processed_transcript |
| 418521 | enst00000582118 | sg00000109065 | nat9-216 | 17 | 74773354 | 74776345 | - | lnc_RNA | retained_intron |
| 418521 | enst00000585240 | sg00000109065 | nat9-229 | 17 | 74772442 | 74776345 | - | lnc_RNA | processed_transcript |
| 418527 | enst00000578798 | sg00000109065 | nat9-203 | 17 | 74772031 | 74776351 | - | lnc_RNA | retained_intron |
| 418527 | enst00000582168 | sg00000109065 | nat9-217 | 17 | 74772994 | 74776351 | - | lnc_RNA | retained_intron |
| 418537 | enst00000577428 | sg00000109065 | nat9-202 | 17 | 74772275 | 74776361 | - | lnc_RNA | processed_transcript |
| 418541 | enst00000582524 | sg00000109065 | nat9-219 | 17 | 74771764 | 74776365 | - | mRNA | protein_coding |
| 418543 | enst00000582993 | sg00000109065 | nat9-221 | 17 | 74773311 | 74776367 | - | lnc_RNA | retained_intron |
| 418543 | enst00000583689 | sg00000109065 | nat9-223 | 17 | 74772777 | 74776367 | - | lnc_RNA | retained_intron |
| 418543 | enst00000584409 | sg00000109065 | nat9-228 | 17 | 74772295 | 74776367 | - | lnc_RNA | processed_transcript |
| 418675 | enst00000417024 | sg00000109066 | tmem104-202 | 17 | 74776499 | 74839752 | + | mRNA | protein_coding |
| 418675 | enst00000335464 | sg00000109066 | tmem104-201 | 17 | 74776499 | 74839753 | + | mRNA | protein_coding |
| 418676 | enst00000582773 | sg00000109066 | tmem104-205 | 17 | 74776500 | 74839751 | + | mRNA | protein_coding |
| 418676 | enst00000578764 | sg00000109066 | tmem104-203 | 17 | 74776500 | 74795589 | + | mRNA | protein_coding |
| 418685 | enst00000584246 | sg00000109066 | tmem104-207 | 17 | 74776509 | 74785680 | + | lnc_RNA | retained_intron |
| 418696 | enst00000582330 | sg00000109066 | tmem104-204 | 17 | 74776520 | 74839750 | + | mRNA | protein_coding |
| -444386 | enst00000659097 | sg00000288006 | ac137735.3-201 | 17 | 73912190 | 73931436 | + | lnc_RNA | lncrna |
| -444698 | enst00000581911 | sg00000266765 | ac137735.1-201 | 17 | 73894749 | 73911878 | - | lnc_RNA | lncrna |
| 479275 | enst00000584171 | sg00000109066 | tmem104-206 | 17 | 74837099 | 74837908 | + | lnc_RNA | processed_transcript |
Source file: /hps/research1/birney/users/adrien/analyses/cancer_DNA_promethion/run_1_2_3_4/DNA_pipeline_2/results/methylation/pycometh_meth_comp_CGI_3/out.tsv.gz
MD5 hash: 9aa0e3f69cb4e12345c3758eb68a5efc